Peptide array synthesis, rna synthesis services
The general strategy is to make a collection of short sequence peptides that gradually span the relevant portion of the known protein sequence by small residue increments. Flexible Aliquoting Options We provide aliquoting services free for the first 5 vials and as little as 0.
Peptide libraries can be manufactured efficiently with automated synthesisers. These have been specially optimized to prevent secondary structure formation during chain growth.
You can view your solubility test results any time by logging into your Account page. Peptide Content Analysis Custom peptides are delivered as a gross peptide consisting of a mixture of the target peptide, peptidic impurities, counter ions, and water.
Our solubility testing service will help you conserve time, money, and peptide stock, by providing the optimal peptide dissolution condition that suits your assay requirements.
You will received a customized solubility test report containing the concentration of your peptide in each of the tested solvents. They can also provide further modifications to your peptides, such as conjugation or services such as affinity purification.
TFA Removal Service removes the residual TFA and replaces it with your choice of acetate or hydrochloride, both of which are more amenable for cell-based assays.
Mimotopes can assist customers with designing epitope mapping libraries. Immunological Applications Peptide libraries are an excellent tool for mapping epitopes on antibodies or T-cells.
Drug Discovery Applications Synthetic peptides at the preclinical stage are primarily used for immunology or drug discovery research. Request peptide content analysis to Peptide array synthesis the precise amount of target peptide in the gross peptide preparation and increase your experimental accuracy.
Mimotopes are leading experts at designing and providing custom peptide libraries for this purpose. Certificate of Analysis The appearance, quantity, molecular weight, and purity of each peptide will be analyzed and included in the certificate of analysis report.
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This approach has proven to be effective in the discovery of cell signalling peptides and protease development, to name a few.
Subsequent assay will determine which of those peptides represents the antigen for the target sequence. Again, peptide libraries provide this tool, offering an expedient way to generate large numbers of analogs and determine their structure activity relationships.
Performing experiments with hydrophobic peptides can be extremely frustrating if Peptide array synthesis are unsure of how to properly dissolve your peptide. Residual TFA in peptide samples can cause cytotoxicity in cell culture assays, therefore TFA removal service is recommended for peptides that will be used in cellular assays.
One of the most useful ways of answering questions about the effectiveness of a peptide vaccine or drug is via peptide libraries. Our peptide synthesis experts perform a systematic dissolution of your peptide in various buffers at varying pH to determine the conditions under which the highest concentration of dissolved peptide can be obtained.
Your peptide is dissolved systematically in lab solvents that are most likely to yield the highest gross peptide Illustration writing essay topics. Additional QC reports are provided for peptides for which this service is performed.
In addition, determining the optimal conditions for dissolution can consume up to 5 mg of your peptide stock. Alternatively, the SynPhase Workstation offers a highly effective and relatively inexpensive means to processing large numbers of Lanterns using the Multipin Array synthesis approach.
All reports can be downloaded by visiting My Account page. Here, the typical strategy involves systematic replacement of each residue in the known target sequence with substitute amino acids. Your peptide sequence's characteristics are evaluated, and a customized solubility testing approach is designed.
Drug Discovery Applications The growing importance of peptides as therapeutics underpins the need for an efficient means to elucidating target sequences in biological systems.
For chemists wishing to synthesise their own peptides, SynPhase combinatorial offers a range of Lanterns featuring a low loading polyamide graft.
These libraries are made at Mimotopes on D-series PA Lanterns, providing unparalleled efficiency and reliability in manufacture.